JRC labs added to the CERIC open access offer
Following the positive evaluation by the International Scientific and Technical Advisory Committee – ISTAC of CERIC, some of the state-of-the-art instruments at the JRC Nanobiotechnology Laboratory in Ispra have been included in the CERIC open access offer.
Such facilities allow interdisciplinary studies with a special emphasis on the characterisation of nanomaterials, nanomedicines, advanced materials, and micro(nano)plastics.
The facility is also equipped with a chemistry laboratory and facilities for the sample preparation necessary to carry out the experiments. The provided service also includes scientific and technical support, thanks to a multidisciplinary team of scientists, including chemists, physicists, biologists, and materials scientists with extensive experience in the fields of physico-chemical characterisation of materials and nanobiosciences.
In particular, the JRC labs can be used for the following purposes:
Techniques enabling orthogonal characterisation of nanomaterials include:
- Asymmetrical field flow field fractionation
- Analytical Ultracentrifugation
- Volume specific surface area
- DCS – Disk Centrifuge Sedimentation
- DLS – Dynamic Light Scattering
- ICP-MS – Inductively Coupled Plasma Mass Spectrometry
- MALS – Multi Angle Light Scattering Detector
- Micro-FTIR – Fourier Trasform InfraRed Spectrometer coupled with a microscope
- TXRF – Total Reflection X-ray Fluorescence
- XRD – X-Ray Diffraction
- TOF-SIMS Time of Flight Secondary Ion Mass Spectrometry
- XPS – X-Ray Photoemission Spectroscopy
- Dual Beam – FIB-SEM focused ion beam and scanning electron microscope
- TEM – Transmission Electron Microscopy
- Microspotter – Non Contact Printing
- AUC – Analytical UltraCentrifugation
- CD – Circular Dichroism
- QCM-D – Quartz Crystal Microbalance
- SPR – Surface Plasmon Resonance
- Cell culture facilities and in vitro cytotoxicity assays
- Fluorescence microscopy and confocal fluorescence microscope
- Microarray scanner
- Multiplex Elisa
- Real-time polymerase chain reaction
The facility for the sample preparation necessary for performing analysis with the previously described techniques, includes:
- Chemistry laboratory with spin coatings, sample digestion apparatus, etc.
- Sample preparation facilities for samples preparation for Electron microscopy
FIELDS OF APPLICATION:
- Nanomaterial synthesis and characterisation
- Surface chemical analysis of nano- and macromaterials
- Detection of nanomaterials and micro(nano)plastics in various environmental compartments and other complex matrices
- Characterisation of interactions of nanomaterials/nanomedicines/nanoplastics with biological systems based on in vitro biocompatibility studies
- Biocompatibility studies incl. cytotoxicity, genotoxicity, immunotoxicity and, nanomaterial uptake studies using various human/animal cell lines, primary cells and stem cells
- Biomolecular interaction studies, in-depth characterisation of antibodies and antigens, bio-interfaces characterisation
- Advanced materials characterisation for applications beyond the biological-medical fields (energy, transport, etc.).