Nano-analytics for Pharmaceutics

CERIC-ERIC offers services based on Nano-analytical and multi-technique methodologies, which will be applied in the project in order to meet the requirements imposed on modern pharmaceutical products, as well as to satisfy new restrictive quality rules. The research team will use Nano-analytical multi-techniques for the development of drug formulations and release in solid, liquid-crystal and liquid state. The examples are systems enclosed with active pharmaceutical ingredients (APIs).

Drug formulations and quality development are very time-consuming and cost-intensive. The PI proposes to work on methodologies based on Nano analytics. The research will impact the therapeutic performance of Nano-systems once administered. Hence, the research project focuses on the application and development of new Nano-methodologies for better medicine.

Principal Investigator: Aden Hodzic

Scientific field(s) and main challenges of the project

The increasing importance of Nano analytics for pharmaceutical technology opens a new field of applications for drug research and quality control by using, applying and developing novel tools. The upcoming (European, national and international) laws and regulations for ensuring quality of products will bring more rigorous rules especially in the pharmaceutical and food industries. Hence, the development/application of new methods that allow useful results in the more sensible Nano-range, may respond to the new requirements and lead to a better quality of development and production as well as to shorter production-times, while avoiding drug side effects and bringing a financial benefit.

Resources and Laboratories

  • XRD Beamline (Italian CERIC partner facility at Elettra Sincrotrone Trieste), Italy
  • SAXS Beamline and SWAXS Laboratory (Austrian CERIC partner facility at the Technical University Graz and in Trieste), Austria/Italy
  • Formulation (micro-particles, nano-particles, particle characterization and in vitro dissolution studies) (KF-Uni Graz), Austria
  • Formulation (liquid crystals drug delivery systems), (Univ. Copenhagen), Denmark
  • NMR (Slovenian CERIC partner facility at the National Institute of Chemistry in Ljubljana), Slovenia
  • SEM, AFM, Optical Methods (Univ. of Latvia), Latvia
  • Neutron Source, (BNC) Hungary
  • Raman (Croatian CERIC facility at the Ruđer Bošković Institute in Zagreb), Croatia
  • Specific Nano-particles preparation (UCL), London – UK

Contact

Aden Hodzic

Publications

  • Comprehensive characterization of nanostructured lipid carriers using laboratory and synchrotron X-ray scattering and diffraction.
    Tetyczka C., Hodzic A., Kriechbaum M., Juraić K., Spirk C., Hartl S., Pritz E., Leitinger E., Roblegg E., European Journal of Pharmaceutics and Biopharmaceutics, 2019, DOI
  • Unravelling the growth mechanism of the co-precipitation of iron oxide nanoparticles with the aid of synchrotron X-Ray diffraction in solution
    LaGrow A.P., Besenhard M.O., Hodzic A., Sergides A., Bogart L.K., Gavrilidis A., Thanh N. T.K., Nanoscale, 2019, DOI

Oral presentations

  • M. Besenhard et al. Presentation at Conference: 10th World Congress of Chemical Engineering (Barcelona / Spain, 2017)
  • A. Hodzic et al. Presentation at Conference: Science @ CERIC, (Hermagor / Austria 2017)
  • A. Hodzic et al. Presentation at Conference: From Materials to Science (Prague / Czech Republic 2018)
  • A. Hodzic et al. Presentation at Conference: SYNERGI2018 (Amsterdam / The Netherlands 2018)
  • A. Hodzic et al. Presentation at Conference: Eurofinish + Materials 2019 (Lueven/ Belgium 2019)
  • C. Tetyczka et al. Presentation at Conference: OPhG (Graz/Austria 2019)
  • M. Besenhard et al. Presentation at Workshop: FlowMat2019 @ Sorbonne University (Paris/France 2019)

Posters

Tetyczka et al. Poster at Conference: 3rd European Conference, Bringing science into pharmaceutical practice (Bologna/Italy 2019)

Research Group

CERIC-ERIC:
Dr. Aden Hodzic

Austrian CERIC partner facility at the Technical University Graz and in Trieste:
Prof. Heinz Amenitsch
Dr. Manfred Kriechenbaum

Croatian CERIC facility at the Ruđer Bošković Institute in Zagreb:
Dr. Krunoslav Juraic

Hungarian CERIC partner facility at the Centre for Energy Research of Science (MTA EK) of the Hungarian Academy of Science (HAS) in Budapest:
Dr. László Szentmiklósi
Dr. Tamás Belgya
Dr. János Füzy

Slovenian CERIC partner facility at the National Institute of Chemistry in Ljubljana:
Prof. Janez Plavec
Dr. Primož Šket

University of Copenhagen – Denmark:
Prof. Anan Yaghmur

EMPA (Material Science and Technology) – Switzerland:
Dr. Stefan Salentinig

Karl-Franzens-Universität Graz – Austria:
Prof. Eva Roblegg

University of Latvia – Riga, Latvia:
Dr. Roman Viter

University College London – United Kingdom:
Dr. Max Besenhard